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1

Development of new antituberculous agents based on new drug targets and structure–activity relationship

Tomioka, Haruaki

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 390 KB

english, 2008

2

Therapeutic Efficacy of Liposome-encapsulated Kanamycin against Mycobacterium intracellulare Infection Induced in Mice

Tomioka, Haruaki, Saito, Hajime, Sato, Katsumasa, Yoneyama, Toshimi

Journal:

American Review of Respiratory Disease

Year:

1991

Language:

english

File:

PDF, 627 KB

english, 1991

3

Mycobacterium malmoense Isolated from Soil

Saito, Hajime, Tomioka, Haruaki, Sato, Katsumasa, Tasaka, Hiromichi, Dekio, Satoshi

Journal:

Microbiology and Immunology

Year:

1994

Language:

english

File:

PDF, 433 KB

english, 1994

4

In vitro drug susceptibility of Mycobacterium bovis BCG Connaught and Tokyo strains

Toshiaki Shimizu, Ko Yasumoto, Yutaka Tatano, Haruaki Tomioka, Katsumasa Sato, Chiaki Sano, Hiromi Kumon, Koichi Monden

Journal:

Journal of Infection

Year:

2010

Language:

english

File:

PDF, 108 KB

english, 2010

5

Development of new antituberculous drugs based on bacterial virulence factors interfering with host cytokine networks

Haruaki Tomioka, Yutaka Tatano, Chiaki Sano, Toshiaki Shimizu

Journal:

Journal of Infection and Chemotherapy

Year:

2011

Language:

english

File:

PDF, 333 KB

english, 2011

6

Prospects for development of new antimycobacterial drugs

Haruaki Tomioka

Journal:

Journal of Infection and Chemotherapy

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

7

Expression profiles of low molecular mass heat shock proteins by Mycobacterium avium and Mycobacterium intracellulare

Haruaki Tomioka, Toshiaki Shimizu, Hiroko Kajitani, Katsumasa Sato, Chiaki Sano

Journal:

FEMS Microbiology Letters

Year:

2001

Language:

english

File:

PDF, 235 KB

english, 2001

8

Comparative in vitro and in vivo activity of rifabutin and rifampicin against mycobacterium avium complex

Hajime Saito, Katsumasa Sato, Haruaki Tomioka

Journal:

Year:

1988

Language:

english

File:

PDF, 498 KB

english, 1988

9

Roles of reactive nitrogen intermediates and transforming growth factor-β produced by immunosuppressive macrophages in the expression of suppressor activity against T cell proliferation induced by TCR stimulation

Toshiaki Shimizu, Shanshan Cai, Haruaki Tomioka

Journal:

Year:

2005

Language:

english

File:

PDF, 169 KB

english, 2005

10

Expression profiles of low molecular mass heat shock proteins by Mycobacterium avium and Mycobacterium intracellulare

Haruaki Tomioka, Toshiaki Shimizu, Hiroko Kajitani, Katsumasa Sato, Chiaki Sano

Journal:

FEMS Microbiology Letters

Year:

2001

Language:

english

File:

PDF, 238 KB

english, 2001

11

Effects of secretory leukocyte protease inhibitor on the tumor necrosis factor-alpha production and NF-κB activation of lipopolysaccharide-stimulated macrophages

Chiaki Sano, Toshiaki Shimizu, Haruaki Tomioka

Journal:

Year:

2003

Language:

english

File:

PDF, 1.07 MB

english, 2003

12

Effects of picolinic acid on the antimicrobial functions of host macrophages against Mycobacterium avium complex

Haruaki Tomioka, Toshiaki Shimizu, Yutaka Tatano

Journal:

International Journal of Antimicrobial Agents

Year:

2007

Language:

english

File:

PDF, 384 KB

english, 2007

13

Comparative in vitro and in vivo antimicrobial activities of sitafloxacin, gatifloxacin and moxifloxacin against Mycobacterium avium

Chiaki Sano, Yutaka Tatano, Toshiaki Shimizu, Seiko Yamabe, Katsumasa Sato, Haruaki Tomioka

Journal:

International Journal of Antimicrobial Agents

Year:

2011

Language:

english

File:

PDF, 562 KB

english, 2011

14

Antimicrobial activities of levofloxacin, clarithromycin, and KRM-1648 against Mycobacterium tuberculosis and Mycobacterium avium complex replicating within Mono Mac 6 human macrophage and A-549 type II alveolar cell lines

Katsumasa Sato, Haruaki Tomioka, Tatsuya Akaki, Shin Kawahara

Journal:

International Journal of Antimicrobial Agents

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

15

Antimicrobial activities of clarithromycin, gatifloxacin and sitafloxacin, in combination with various antimycobacterial drugs against extracellular and intramacrophage Mycobacterium avium complex

Haruaki Tomioka, Chiaki Sano, Katsumasa Sato, Toshiaki Shimizu

Journal:

International Journal of Antimicrobial Agents

Year:

2002

Language:

english

File:

PDF, 363 KB

english, 2002

16

Evaluation of in vivo therapeutic efficacy of a new benzoxazinorifamycin,KRM-1648, in SCID mouse model for disseminated Mycobacterium avium complex infection

Masako Emori, Haruaki Tomioka, Katsumasa Sato, Hajime Saito

Journal:

International Journal of Antimicrobial Agents

Year:

1998

Language:

english

File:

PDF, 215 KB

english, 1998

17

Effects of Yokuinin on the therapeutic efficacy of a new benzoxazinorifamycin KRM-1648 against Mycobacterium avium infection

Toshiaki Shimizu, Haruaki Tomioka, Katsunasa Sato, Chiaki Sano, Yoshitaka Yamada, Hiroki Shibata, Natsumi Higashi

Journal:

International Journal of Antimicrobial Agents

Year:

1999

Language:

english

File:

PDF, 132 KB

english, 1999

18

Recent advances in antituberculous drug development and novel drug targets

Tomioka, Haruaki, Tatano, Yutaka, Yasumoto, Ko, Shimizu, Toshiaki

Journal:

Expert Review of Respiratory Medicine

Year:

2008

Language:

english

File:

PDF, 477 KB

english, 2008

19

In vitro and in vivo activities of KRM-1648, a newly synthesized benzoxazinorifamycin, against mycobacterium marinum

Yamamoto, Yukari, Saito, Hajime, Tomioka, Haruaki, Sato, Katsumasa, Yamane, Takehiko, Yamashita, Katsuji, Hosoe, Kazunori, Hidaka, Takayoshi

Journal:

Zentralblatt für Bakteriologie

Year:

1992

Language:

english

File:

PDF, 575 KB

english, 1992

20

Marine meteorology

Yamamoto, Yukari, Saito, Hajime, Tomioka, Haruaki, Sato, Katsumasa, Yamane, Takehiko, Yamashita, Katsuji, Hosoe, Kazunori, Hidaka, Takayoshi

Journal:

Deep Sea Research Part B. Oceanographic Literature Review

Year:

1982

Language:

english

File:

PDF, 312 KB

english, 1982

21

In vitro and in vivo activities of clarithromycin against the Mycobacterium avium complex

Hajime Saito,, Haruaki Tomioka,, Katsumasa Sato,, Satoshi Dekio,

Journal:

International Journal of Antimicrobial Agents

Year:

1994

Language:

english

File:

PDF, 680 KB

english, 1994

22

Type II pneumocytes in the evaluation of drug antimycobacterial activity

Tomioka, Haruaki

Journal:

Expert Opinion on Pharmacotherapy

Year:

2003

Language:

english

File:

PDF, 220 KB

english, 2003

23

Antimicrobial Activities of Cinnamyl Rifamycin Derivatives, T-9 and T-11, against Mycobacterium tuberculosis and Mycobacterium avium Complex (MAC) with Special Reference to the Activities against Intracellular MAC

Sato, Katsumasa, Shimizu, Toshiaki, Dimova, Velitchka, Tomioka, Haruaki

Journal:

Microbiology and Immunology

Year:

2006

Language:

english

File:

PDF, 164 KB

english, 2006

24

Effects of Type II Alveolar Epithelial Cells on T Cell Mitogenic Responses to Concanavalin A and Purified Protein Derivatives

Sato, Katsumasa, Shimizu, Toshiaki, Sano, Chiaki, Tomioka, Haruaki

Journal:

Microbiology and Immunology

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

25

Improvement of C-Reactive Protein Levels and Body Temperature of an Elderly Patient Infected with Pseudomonas aeruginosa on Treatment with Mao-Bushi-Saishin-To

Kamei, Tsutomu, Kondoh, Tatsuro, Nagura, Satoshi, Toriumi, Yoshitaka, Kumano, Hiroaki, Tomioka, Haruaki

Journal:

Journal of Alternative and Complementary Medicine

Year:

2000

Language:

english

File:

PDF, 439 KB

english, 2000

26

ATP Exhibits Antimicrobial Action by Inhibiting Bacterial Utilization of Ferric Ions

Tatano, Yutaka, Kanehiro, Yuichi, Sano, Chiaki, Shimizu, Toshiaki, Tomioka, Haruaki

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

27

Unique Macrophages Different from M1/M2 Macrophages Inhibit T Cell Mitogenesis while Upregulating Th17 Polarization

Tatano, Yutaka, Shimizu, Toshiaki, Tomioka, Haruaki

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 1.97 MB

english, 2014

28

Current Status of Some Antituberculosis Drugs and the Development of new Antituberculous Agents with Special Reference to their In Vitro and In Vivo Antimicrobial Activities

Tomioka, Haruaki

Journal:

Current Pharmaceutical Design

Year:

2006

Language:

english

File:

PDF, 198 KB

english, 2006

29

Letter to the Editor: Effect of Half the Standard Dose of Mao-Bushi-Saishin-To in Two MRSA Patients and One Decubitus Ulcer Patient

Kamei, Tsutomu, Nagura, Satoshi, Toriumi, Yoshitaka, Kumano, Hiroaki, Kondoh, Tatsuko, Tomioka, Haruaki

Journal:

The American Journal of Chinese Medicine

Year:

2000

Language:

english

File:

PDF, 239 KB

english, 2000

30

Type II Alveolar Cells Play Roles in Macrophage‐Mediated Host Innate Resistance to Pulmonary Mycobacterial Infections by Producing Proinflammatory Cytokines

Sato, Katsumasa, Tomioka, Haruaki, Shimizu, Toshiaki, Gonda, Tatsuo, Ota, Fusao, Sano, Chiaki

Journal:

The Journal of Infectious Diseases

Year:

2002

Language:

english

File:

PDF, 776 KB

english, 2002

31

Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages

Tomioka, Haruaki, Tatano, Yutaka, Maw, Win Win, Sano, Chiaki, Kanehiro, Yuichi, Shimizu, Toshiaki

Journal:

Clinical & Developmental Immunology

Year:

2012

Language:

english

File:

PDF, 294 KB

english, 2012

32

Sex Differences in the Susceptibility of Mice to Infection Induced by Mycobacterium intracellulare

Yamamoto, Yukari, Tomioka, Haruaki, Sato, Katsumasa, Saito, Hajime, Yamada, Yoshitaka, Setogawa, Tomoichi

Journal:

American Review of Respiratory Disease

Year:

1990

Language:

english

File:

PDF, 419 KB

english, 1990

33

Suppression of Phorbol Myristate Acetate-Triggering of Macrophage H 2 O 2 Release by Sarcoma 180 Originating Factor

Tomioka, Haruaki, Saito, Hajime

Journal:

Microbiology and Immunology

Year:

1985

Language:

english

File:

PDF, 1.29 MB

english, 1985

34

Comparison of Wheat Germ Agglutinin- and Phorbol Myristate Acetate-Mediated Triggering for Macrophage H 2 O 2 Release

Tomioka, Haruaki, Saito, Hajime

Journal:

Microbiology and Immunology

Year:

1987

Language:

english

File:

PDF, 1.17 MB

english, 1987

35

Effect of Phorbol Myristate Acetate, a Tumor-Promoting Agent, on the Growth of Mycobacterium lepraemurium in the Mouse Footpad

Tomioka, Haruaki, Saito, Hajime

Journal:

Microbiology and Immunology

Year:

1983

Language:

english

File:

PDF, 1.10 MB

english, 1983

36

Comparative Profiles of Intramacrophage Behavior of Mycobacterium tuberculosis and Mycobacterium avium Complex with Different Levels of Virulence

Sano, Keisuke, Sato, Katsumasa, Sano, Chiaki, Shimizu, Toshiaki, Tomioka, Haruaki

Journal:

Microbiology and Immunology

Year:

2002

Language:

english

File:

PDF, 47 KB

english, 2002

37

Comparison of the Virulence for Mice of Mycobacterium avium and Mycobacterium intracellulare Identified by DNA Probe Test

Tomioka, Haruaki, Saito, Hajime, Sato, Katsumasa, Dawson, David J.

Journal:

Microbiology and Immunology

Year:

1993

Language:

english

File:

PDF, 1011 KB

english, 1993

38

Dual Effects of OK-432 on Mitogenic Response of Splenocytes to Concanavalin A

Tomioka, Haruaki, Saito, Hajime, Nagashima, Kiyofumi

Journal:

Microbiology and Immunology

Year:

1985

Language:

english

File:

PDF, 1.29 MB

english, 1985

39

Enhancement of Host Resistance against Listeria Infection by Lactobacillus casei : Efficacy of Cell Wall Preparation of Lactobacillus casei

Sato, Katsumasa, Saito, Hajime, Tomioka, Haruaki, Yokokura, Teruo

Journal:

Microbiology and Immunology

Year:

1988

Language:

english

File:

PDF, 1.45 MB

english, 1988

40

Experimental and Clinical Studies on Rifacinna® - The New Effective Antituberculous Drug (Review)

Velichka, Dimova, Ivana, Atanasova, Haruaki, Tomioka, Katsumasa, Sato, Venkata, Reddy, Nadadhur, Geeta, Donna, Daneluzzi, Patisapu, Gangadharam, Todor, Kantardjiev, Arvind, Dhople, Yurii, Feshchenko,

Journal:

Recent Patents on Anti-Infective Drug Discovery

Year:

2010

Language:

english

File:

PDF, 509 KB

english, 2010

41

Suppressive Activity of Splenic Macrophages Induced by Transparent and Opaque Colonial Variants of Mycobacterium avium Complex against Lymphoproliferative Response

Tomioka, Haruaki, Saito, Hajime

Journal:

Microbiology and Immunology

Year:

1993

Language:

english

File:

PDF, 1.40 MB

english, 1993

42

Physicochemical Characterization of Tween 80-Hydrolyzing Esterases Produced by Rapidly Growing Mycobacteria

Tomioka, Haruaki, Yoneyama, Toshimi, Asano, Kyoko, Watanabe, Takashi, Saito, Hajime

Journal:

Microbiology and Immunology

Year:

1983

Language:

english

File:

PDF, 668 KB

english, 1983

43

Susceptibility of Mycobacterium avium and Mycobacterium intracellulare to Various Antibacterial Drugs

Tomioka, Haruaki, Sato, Katsumasa, Saito, Hajime, Yamada, Yoshitaka

Journal:

Microbiology and Immunology

Year:

1989

Language:

english

File:

PDF, 643 KB

english, 1989

44

Supplement 5. Second International Symposium on New Quinolones || Efficacy of Ofloxacin and Ciprofloxacin against Experimental Mycobacterium kansasii Infections in Mice

Hajime Saito and Haruaki Tomioka

Journal:

Reviews of Infectious Diseases

Year:

1989

Language:

english

File:

PDF, 268 KB

english, 1989

45

Characteristics of Immunosuppressive Macrophages Induced in Host Spleen Cells by Mycobacterium avium Complex and Mycobacterium tuberculosis Infections in Mice

Tomioka, Haruaki, Saito, Hajime, Sato, Katsumasa

Journal:

Microbiology and Immunology

Year:

1990

Language:

english

File:

PDF, 1.66 MB

english, 1990

46

Supplement 1. International Symposium on New Quinolones || Susceptibility of Various Mycobacteria to Quinolones

Hajime Saito, Takashi Watanabe, Haruaki Tomioka and Katsumasa Sato

Journal:

Reviews of Infectious Diseases

Year:

1988

Language:

english

File:

PDF, 222 KB

english, 1988

47

Prospects for the Development of New Antituberculous Drugs Based on the Drug Targets Related to Virulence Factors Interfering with Host Cytokine Networks

TOMIOKA, Haruaki

Journal:

Kansenshogaku zasshi

Year:

2012

File:

PDF, 433 KB

2012

48

Effects of Various Steroidal and Non-Steroidal Anti-Inflammatory Drugs on In-Vitro IL-10 Production of Murine Peritoneal Macrophages Infected with Mycobacterium avium Complex

SHIMIZU, Toshiaki, SANO, Chiaki, SATO, Katsumasa, TOMIOKA, Haruaki

Journal:

Kansenshogaku zasshi

Year:

1997

File:

PDF, 2.66 MB

1997

49

Profiles of Intracellular Expression, Distribution, and Activation of Phospholipase A2 in Host Macrophages Infected with Mycobacterium avium complex

SANO, Chiaki, SHIMIZU, Toshiaki, TATANO, Yutaka, YASUMOTO, Ko, TOMIOKA, Haruaki

Journal:

Kansenshogaku zasshi

Year:

2007

File:

PDF, 1.32 MB

2007

50

Profiles of the Expression of Phospholipase A2 Family mRNAs by Macrophages Infected with Mycobacterium tuberculosis

SANO, Chiaki, SHIMIZU, Toshiaki, SATO, Katsumasa, TOMIOKA, Haruaki

Journal:

Kansenshogaku zasshi

Year:

2004

File:

PDF, 2.25 MB

2004